Pathogens isolated from respiratory tract secretions and expressions of serum NO,MMP-2 and IL-8 in epiglottic cyst infection patients complicated with acute epiglottitis
10.11816/cn.ni.2025-240704
- VernacularTitle:会厌囊肿感染并发急性会厌炎呼吸道分泌物病原菌及血清NO、MMP-2、IL-8表达
- Author:
Yingliang HUANG
1
;
Jian ZHANG
1
;
Kailin JIN
1
Author Information
1. 杭州市临平区第一人民医院耳鼻咽喉科,浙江 杭州 311100
- Publication Type:Journal Article
- Keywords:
Epiglottic cyst;
Infection;
Acute epiglottitis;
Pathogen;
Nitric oxide;
Matrix metalloproteinase-2;
In-terleukin-8;
Recurrence
- From:
Chinese Journal of Nosocomiology
2025;35(5):687-691
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the distribution of pathogens isolated from respiratory tract secretions,observe the expressions of serum nitric oxide(NO),matrix metalloproteinase-2(MMP-2)and interleukin-8(IL-8)in the epiglottic cyst infection patients complicated with acute epiglottitis,and analyze the clinical significance.METHODS The clinical data were collected from 98 epiglottic cyst infection patients complicated with acute epi-glottitis who were treated in the First People's Hospital of Linping District from Jan.2019 to Jun.2023.The dis-tribution of pathogens isolated from the respiratory tract secretions was recorded.Among the enrolled patients,45 patients who received conservative therapy were assigned as the non-surgery group,and 53 patients who under-went electrotome resection under self-retaining laryngoscope were assigned as the surgery group.The levels of ser-um NO,MMP-2 and IL-8 were compared between the two groups of patients,the recurrence rate was observed and compared after the discharge for 6 months.The values of serum NO,MMP-2 and IL-8 at the admission in prediction of recurrence of the non-surgery group 6 months after the surgery were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Totally 61 strains of pathogens were isolated from the 98 pa-tients,63.93％of which were gram-negative bacteria,and 36.07％were gram-positive bacteria.The levels of ser-um NO,MMP-2 and IL-8 of the two groups were lower after the discharge than at the admission(P＜0.05),which were lower on the 7th day of admission than on the 3rd day of admission(P＜0.05).The levels of serum NO,MMP-2 and IL-8 of the surgery group were lower than those of the non-surgery group on the 7th day of dis-charge(P＜0.05).The recurrence rate of the surgery group was 0 after the discharge for 6 months,lower than 13.33％of the non-surgery group(0.00％vs.13.33％,continuity correction x2=5.387,P=0.020).ROC curve a-nalysis showed that the levels of serum NO,MMP-2 and IL-8 at the admission had statistical significance in pre-diction of recurrence 6 months after the discharge(P＜0.05).CONCLUSION As compared with conservative thera-py,the electrotome resection under self-retaining laryngoscope may reduce the recurrence rate of acute epiglottitis in the epiglottic cyst infection patients,and the levels of serum NO,MMP-2 and IL-8 can assist the prediction of risk of recurrence.
