Research Progress in Corni Fructus and Its Active Components for the Prevention and Treatment of Neurodegenerative Diseases
10.19879/j.cnki.1005-5304.202404510
- VernacularTitle:山茱萸及其有效成分防治神经退行性疾病研究进展
- Author:
Jialin YAO
1
;
Lufeng BAI
;
Yunxiang GUAN
;
Baicheng QIAN
;
Haofan GAO
;
Baoliang WANG
Author Information
1. 河南中医药大学第一临床医学院,河南 郑州 450046;河南中医药大学第一附属医院脑病中心,河南 郑州 450000
- Publication Type:Journal Article
- Keywords:
Corni Fructus;
neurodegenerative diseases;
active components;
mechanism
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(5):187-192
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases(NDs)are a series of disorders characterized by varying degrees of cognitive and mobility impairment,with increasing incidence in recent years.Currently,the treatment of these diseases is mainly based on drug therapy,and there are no effective methods for reversing the course of the diseases.Corni Fructus has the efficacy of tonifying the liver and kidney,and astringency and arresting,which is effective to various types of NDs.This article summarized the pharmacological effects of Corni Fructus,including anti-inflammatory,anti-oxidative stress,regulation of mitochondrial function,modulation of autophagy,inhibition of neuronal apoptosis,and epigenetic modulation,and sorted out the research progress of Corni Fructus and its active components in the treatment of NDs,such as Alzheimer disease,Parkinson disease,multiple sclerosis,and so on,with a view to providing a reference for further research and clinical application of Corni Fructus in NDs.
