Clinical distribution and drug resistance of common pathogens in a hospital of Guangzhou from 2017 to 2023
10.11816/cn.ni.2025-241129
- VernacularTitle:2017-2023年广州某医院常见病原菌临床分布和耐药性
- Author:
Yuhua LI
1
;
Kesheng HU
;
Zhenglin ZHU
;
Weihao ZOU
;
Ping GE
;
Lili YANG
;
Biyun WANG
;
Hongjuan PENG
Author Information
1. 南方医科大学公共卫生学院病原生物学系,广东省热带病研究重点实验室,华南传染病防治教育部重点实验室(南方医科大学),广东 广州 510515;武警广东总队医院检验与病理科,广东 广州 510507
- Publication Type:Journal Article
- Keywords:
Pathogen;
Antibiotic;
Clinical distribution;
Drug resistance;
Hospital-associated infection
- From:
Chinese Journal of Nosocomiology
2025;35(5):769-775
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the clinical distribution and drug resistance of common species of pathogens iso-lated from a three-A hospital of Guangzhou from Jan.2017 to 2023 Dec.so as to provide bases for clinical diagno-sis and reasonable use of antibiotics.METHODS A total of 10,086 strains of aerobic bacteria were clinically isola-ted from the patients who were hospitalized in a three-A hospital of Guangzhou from 2017 to 2023.The constituent ratios of the common species of pathogens,specimen sources,distribution of departments and drug resistance rates to commonly used antibiotics were retrospectively analyzed.RESULTS Totally 10,086 strains of pathogens were isolated from the specimens of the hospitalized patients from 2017 to 2023.Klebsiella pneumoniae,Pseudo-monas aeruginosa,Escherichia coli,Acinetobacter baumannii and Staphylococcus aureus ranked the top 5 species of pathogens.The sputum,midstream urine and whole blood were the major specimen sources.The hospital-asso-ciated infection was highly prevalent in critical care medicine department,neurology department,geriatrics depart-ment,neurosurgery department and urology department.The result of drug resistance showed that the drug re-sistance rates of the K.pneumoniae and P.aeruginosa strains to various types of antibiotics showed upward trends(P＜0.05);the drug resistance rate of the A.baumannii strains to imipenem was decreased,while the drug resist-ance rates to most of the antibiotics were more than 45％.No gram-positive cocci strains that were resistant to vancomycin,teicoplanin or linezolid were found.CONCLUSIONS The common clinical isolates of pathogens are generally resistant to antibiotics.It is necessary for clinicians to attach great importance to the culture of pathogens and drug susceptibility testing and reasonably use antibiotics based on the result of drug susceptibility testing so as to reduce the occurrence and spread of drug-resistant strains.The hospital should strengthen the surveillance of drug resistance of bacteria so as to boost the clinical curative effect,standardize the management and use of antibi-otics and take effective measures to control of the hospital-associated infection.
