Sinus bradycardia associated with cyclosporine
10.3760/cma.j.issn.1008-5734.2016.02.017
- VernacularTitle:环孢素相关窦性心动过缓
- Author:
Yao LIANG
1
;
Zhaoyang DU
;
Lulu SUN
Author Information
1. 100038 首都医科大学附属北京世纪坛医院药剂科; 北京大学药学院药事管理与临床药学系
- Publication Type:Journal Article
- Keywords:
CYclosporine;
BradYcardia;
Immunosuppressive agents
- From:
Adverse Drug Reactions Journal
2016;18(2):145-146
- CountryChina
- Language:Chinese
-
Abstract:
A 35-Year-old male patient received oral methYlprednisolone 40 mg twice dailY and mYcophenolate mofelil 750 mg twice dailY for hepatocirrhosis and portal hYpertension induced bY graft-versus-host disease. The heart rate was 76 times/min and electrocardiographY was normal before medication use. On daY 10,the sYmptom did not marKedlY improve,then an Iv infusion of cYclosporine 1. 25 mg/(Kg·d) was added. About 30 minutes after the second infusion of cYclosporine,the patient developed chest distress and the electrocardiographY showed bradYcardia( heart rate was 46 beats/min). CYclosporine was stopped. MethYlprednisolone and mYcophenolate mofelil were still used. Three daYs later,the heart rate was increased to 76 beats/min.
