Evaluation of left atrial function in hypertrophic cardiomyopathy patients with heart failure with preserved ejection fraction by four-dimensional automatic left atrial quantifacation analysis technology
10.3760/cma.j.cn131148-20250507-00257
- VernacularTitle:四维自动左心房定量分析技术评价肥厚型心肌病合并射血分数保留型心力衰竭患者左心房功能
- Author:
Tianyu HUANG
1
;
Ting WU
;
Jiaxin LI
;
Qingqing ZHAO
;
Cunying CUI
;
Chengzeng WANG
;
Lin LIU
Author Information
1. 郑州大学第一附属医院超声医学科 河南省慢病防治与智慧健康管理重点实验室，郑州 450052
- Publication Type:Journal Article
- Keywords:
Four-dimensional automatic left atrial quantification;
Cardiomyopathy，hypertrophic;
Heart failure with preserved ejection fraction;
Atrial function，left
- From:
Chinese Journal of Ultrasonography
2025;34(11):950-957
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the left atrial function in patients with hypertrophic cardiomyopathy（HCM）combined with heart failure with preserved ejection fraction（HFpEF）using four-dimensional automated left atrial quantification（4D Auto LAQ）technology，and to investigate the independent factors affecting patients with HCM combined with HFpEF.Methods:One hundred HCM patients with left ventricular ejection fraction（LVEF）≥ 50% who were admitted to the First Affiliated Hospital of Zhengzhou University from September 2023 to March 2025 were prospectively selected. There were 50 cases in the HFpEF group and 50 cases in the non-HF group. The clinical data and conventional ultrasound parameters of HCM patients were collected. The 4D Auto LAQ technology was applied to obtain the four-dimensional volume and strain parameters of the left atrium，including the minimum left atrial volume（LAVmin），the maximum left atrial volume（LAVmax），the maximum left atrial volume index（LAVImax），the pre-atrial contraction volume（LAVpreA），the left atrial emptying volume（LAEV），the left atrial ejection fraction（LAEF），the longitudinal and circumferential strains in the left atrial reservoir period（LASr，LASr-c），the longitudinal and circumferential strains in the left atrial conduit period（LAScd，LAScd-c），the longitudinal and circumferential strains in the left atrial contraction period（LASct，LASct-c），and the minimum left atrial volume index（LAVImin）. The differences in the above parameters between the two groups were compared. Univariate and multivariate Logistic regression analyses were used to analyze the independent influencing factors in HCM patients with HFpEF. The intraclass correlation coefficient was used to test the repeatability of the 4D Auto LAQ parameters.Results:Compared with the non-HF group，LAVmin，LAVmax，LAVpreA，LAVImin，and LAVImax increased，while LAEF，LASr，LAScd，LASct，LASr-c，LAScd-c，and LASct-c decreased in the HFpEF group（all P<0.05）. Multivariate Logistic regression analysis showed that LASr was the strongest independent influencing factor in patients with HCM combined with HFpEF（ OR=0.255， P=0.003）. The consistency test showed that the intraclass correlation coefficients of each parameters of 4D Auto LAQ were all>0.7，the consistency was good. Conclusions:4D Auto LAQ technology can be used to evaluate left atrial function in patients with HCM combined with HFpEF，and LASr is the strongest independent influence factor in patients with HCM combined with HFpEF.
