Differences in clinical-pathological-ultrasound features among hepatocellular carcinoma with different des-gamma-carboxy prothrombin status
10.3760/cma.j.cn131148-20250211-00065
- VernacularTitle:不同异常凝血酶原状态的肝细胞癌间临床、病理及超声特征分析
- Author:
Feihang WANG
1
;
Yadan XU
;
Yanni CHEN
;
Kai YUAN
;
Wentao KONG
;
Yi DONG
;
Yijie QIU
;
Wenping WANG
Author Information
1. 复旦大学附属中山医院超声科 上海市影像医学研究所，上海 200032
- Publication Type:Journal Article
- Keywords:
Contrast-enhanced ultrasound;
Hepatocellular carcinoma;
Des-gamma-carboxy prothrombin
- From:
Chinese Journal of Ultrasonography
2025;34(8):662-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the differences between clinical-pathological-ultrasound features in hepatocellular carcinoma（HCC）with negative and positive des-gamma-carboxy prothrombin（DCP）.Methods:A retrospective analysis was conducted on 649 patients with pathologically confirmed HCC at Zhongshan Hospital，Fudan University from April 2020 to May 2024. Patients were stratified into DCP-negative（177 cases，<40 mAU/ml）and DCP-positive（472 cases，≥40 mAU/ml）groups. Clinical data，pathological features，and ultrasound findings were collected. Conventional ultrasound and contrast-enhanced ultrasound（CEUS）imaging characteristics were analyzed and compared between the two groups，and the correlation between ultrasound features and pathological characteristics were analyzed.Results:The DCP-negative group exhibited a lower incidence of microvascular invasion（10.17% vs. 34.75%， P<0.001）and smaller median tumor diameter（23 mm vs. 40 mm， P<0.001）. Heterogeneous internal echogenicity was less frequent in DCP-negative tumors［48.59%（86/177） vs. 74.58%（352/472）， P<0.001］. CEUS revealed higher rates of arterial-phase iso-enhancement（6.78% vs. 1.69%）and absence of washout（13.56% vs. 4.45%）in DCP-negative HCC（both P<0.001）. CEUS LI-RADS classification showed fewer LR-5 lesions［50.85%（90/177） vs. 59.53%（281/472）］in DCP-negative group（ P<0.001）. Conclusions:HCC with different DCP states has different clinical-pathological-ultrasound features. DCP-negative HCCs are more likely to show atypical enhancement patterns characteristic of HCC.
