Clinical effects of Yifei Tongluo Decoction combined with azithromycin on patients with childern severe Mycoplasma pneumoniae pneumonia due to Toxic Heat Blocking Lung
10.3969/j.issn.1001-1528.2025.04.015
- VernacularTitle:益肺通络汤联合阿奇霉素对毒热闭肺证儿童重症肺炎支原体肺炎患者的临床疗效
- Author:
Shu-ling WANG
1
;
Yu-qing GUO
;
Xiao-yang TANG
;
Yan ZHANG
;
Yan-rong GUO
;
Xiao-song CHEN
Author Information
1. 无锡市儿童医院中医科,江苏无锡 214023
- Publication Type:Journal Article
- Keywords:
Yifei Tongluo Decoction;
azithromycin;
Mycoplasma pneumoniae pneumonia;
Toxic Heat Blocking Lung
- From:
Chinese Traditional Patent Medicine
2025;47(4):1162-1167
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Yifei Tongluo Decoction combined with azithromycin on patients with childern severe Mycoplasma pneumoniae pneumonia due to Toxic Heat Blocking Lung.METHODS One hundred and fifty-six patients were randomly assigned into control group(78 cases)for 7-day administration of azithromycin,and observation group(78 cases)for 7-day administration of both Yifei Tongluo Decoction and azithromycin.The changes in clinical effects,disappearance time of local symptoms,mycoplasmas,pulmonary imaging score,Toxic Heat Blocking Lung score,pulmonary function indices(PEF,VPTEF,MMF,TPTEF),inflammatory factors(sB7-H3,Cgp-39,sICAM-1,CCL5),immune function indices(RBC-C3bR,RBC-ICR,CD3+,CD4+)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05),along with shorter disappearance time of local symptoms(P＜0.05).After the treatment,the two groups displayed decreased mycoplasmas,pulmonary imaging score,Toxic Heat Blocking Lung score,inflammatory factors,RBC-ICR(P＜0.05),and increased pulmonary function indices,RBC-C3bR,CD3+,CD4+(P＜0.05),especially for the observation group(P＜0.05).No obvious difference in incidence of adverse reactions was found between the two groups(P＞0.05).CONCLUSION For the patients with childern severe Mycoplasma pneumoniae pneumonia due to Toxic Heat Blocking Lung,Yifei Tongluo Decoction combined with azithromycin can safely and effectively alleviate clinical symptoms,improve pulmonary functions,and reduce body inflammatory responses.
