Chemical constituents from the roots of Siraitia grosvenorii and their α-glucosidase inhibitory activities
10.3969/j.issn.1001-1528.2025.04.018
- VernacularTitle:罗汉果根化学成分及其α-葡萄糖苷酶抑制活性研究
- Author:
Si-yu WEI
1
;
Yu-lu WEI
;
Feng-lai LU
;
Wen-long LONG
;
Xiao-hua JIANG
Author Information
1. 广西师范大学生命科学学院,广西桂林 541006;广西植物功能物质与资源持续利用重点实验室,广西壮族自治区中国科学院广西植物研究所,广西桂林 541006
- Publication Type:Journal Article
- Keywords:
Siraitia grosvenorii(Swingle)C.Jeffrey;
roots;
chemical constituents;
isolation and identification;
α-glucosidase;
molecular docking
- From:
Chinese Traditional Patent Medicine
2025;47(4):1181-1188
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the roots of Siraitia grosvenorii(Swingle)C.Jeffrey and their α-glucosidase inhibitory activities.METHODS The 95％ethanol extract was isolated and purified by silica gel,MCI,ODS and HSCCC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The α-glucosidase inhibitory activities were evaluated by PNPG method,after which molecular docking was performed.RESULTS Twenty-one compounds were isolated and identified as vanillin(1),siraitic acid B(2),cucurbitacin B(3),salicylic acid(4),ferulic acid(5),p-hydroxybenzaldehyde(6),(+)-lariciresinol(7),(+)-isolariciresinol(8),liballinol(9),3-(hydroxyacetyl)indole(10),2E-4-hydroxy-nonenoic acid(11),vomifolilol(12),vanillic acid(13),indole-3-carboxylic acid(14),ω-hydroxypropioguaiacone(15),p-hydroxybenzoic acid(16),p-coumaric acid(17),dehydrodipinocarpine(18),secoisolariciresinol(19),sesquimarocanol A(20),threo-guaiacylglycerol-β-O-4-lariciresinol ether(21).IC50 values of compounds 4,10,18 and 21 were(0.42±0.060)-(0.89±0.037)mg/mL.CONCLUSION Compounds 4,10-12,15,16,18,and 21 are isolated from the roots of this plant for the first time.Compounds 4,10,18,21 have α-glucosidase inhibitory activities,and 18 has the strongest activity.
