Preliminary study of carotid artery elasticity and intima thickness changes as assessed by ultrahigh-frequency ultrasound in combination with RF-data based quantitative analysis on vessel stiffness and the influencing factors in patients with ankylosing spondylitis
10.3760/cma.j.cn131148-20241008-00518
- VernacularTitle:超高频超声联合全息血管硬度分析技术评估强直性脊柱炎患者颈动脉弹性和内膜厚度变化及其影响因素
- Author:
Chengkai WU
1
;
Jianjun YUAN
;
Tianshu CHU
;
Xijun ZHANG
;
Fan GAO
;
Ming WU
;
Yanyan GUO
;
Haohui ZHU
Author Information
1. 新乡医学院河南省人民医院，郑州 450003
- Publication Type:Journal Article
- Keywords:
Ultrahigh-frequency ultrasound;
Ankylosing spondylitis;
Carotid artery elasticity;
Carotid intima thickness;
Epicardial adipose tissue thickness
- From:
Chinese Journal of Ultrasonography
2025;34(3):194-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the changes of carotid intima thickness（CIT）and stiffness parameters in ankylosing spondylitis（AS）patients by 24 MHz ultra-high frequency ultrasound probe and RF-data based quantitative analysis on vessel stiffness（R-VQS），and to explore its influencing factors.Methods:Sixty patients with AS who underwent consultation at Henan Provincial People's Hospital from November 2023 to May 2024 were prospectively collected as AS group，54 healthy volunteers matched for sex，age，and body mass index were collected as control group. CIT were measured using a 24 MHz ultra-high frequency ultrasound probe，hardness coefficien（HC）and pulse wave velocity（PWV）were measured by R-VQS，the differences of the parameters between the two groups were compared. The changes of carotid artery elasticity and intima thickness and their influencing factors in patients with AS were explored by univariate and multivariate linear regression analysis.Results:①C-reactiveprotein，erythrocyte sedimentation rate（ESR），neutrophil count and neutrophil to lymphocyte ratio（NLR）were elevated in the AS group compared with the control group，and the differences were statistically significant（all P < 0.05）. ②CIT，carotid intima-media thickness（CIMT），HC，PWV and epicardial adipose tissue thickness（EATT）were all increased in the AS group compared with the control group，and the differences were statistically significant（all P < 0.05）. ③Multifactorial linear regression analysis showed that EATT，ESR were the main influencing factors of HC，PWV and CIT（ β=2.192，0.031；1.792，0.002；0.097，0.001；all P＜0.05）. Conclusions:Carotid CIT，CIMT，HC，PWV and EATT are all higher in the AS patients，and ESR and EATT are the main influencing factors of HC，PWV，and CIT，suggesting that more attention should be paid to the detection of ESR and EATT in patients with AS when interventions are performed clinically.
