Preparation of sustained-release microspheres of ginsenosides
10.3969/j.issn.1001-1528.2025.04.005
- VernacularTitle:人参皂苷缓释微球制备
- Author:
Xiang-ying LIU
1
;
Ru-nan HE
;
Gao QIU
;
Zong-hao LIN
;
Yu-hai GUO
;
Chu-qin YU
Author Information
1. 广东药科大学/广东省药物新剂型重点实验室/广东省局部精准药物递药制剂工程技术研究中心,广东 广州 510006
- Publication Type:Journal Article
- Keywords:
ginsenosides;
sustained-release microspheres;
preparation process;
poly(lactic-co-glycolic acid)(PLGA);
emulsification technology
- From:
Chinese Traditional Patent Medicine
2025;47(4):1097-1104
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare the sustained-release microspheres of ginsenosides.METHODS The sustained-release microspheres were prepared by SPG membrane emulsification technology with poly(lactic-co-glycolic acid)(PLGA)as a shell carrier.With PLGA concentration,feed rate and Span 60 concentration as influencing factors,comprehensive score for appearance,drug loading and encapsulation efficiency as an evaluation indice,the preparation process was optimized by response surface method.The morphology of sustained-release microspheres was observed,after which the particle size,drug loading and encapsulation efficiency were determined,and the in vitro drug release was investigated.RESULTS The optimal conditons were determined to be 45 s for agitation time of primary emulsion,74.68 mg/mL for PLGA concentration,11％for feed rate,and 4.18 mg/mL for Span 60 concentration,the comprehensive score was 74.98.The round sustained-release microspheres demonstrated the average particle size of 4.33 μm,drug loading of(8.24±0.13)％,and encapsulation efficiency of(74.94±1.17)％,respectively.At 336 h,ginsenosides Rg1,Rb1,Rb2 displayed the accumulative release rates of 84.12％,78.04％,65.88％,respectively.CONCLUSION This reasonable and feasible method can be used for the preparation of sustained-release microspheres of ginsenosides with good appearance and high drug loading,which can provide references for the preparation of other water-soluble drug microspheres and solution of microsphere collapse problem.
