Three-dimensional ultrasonography assessment of fetal auricle for predicting congenital aural atresia
10.3760/cma.j.cn131148-20240925-00507
- VernacularTitle:三维超声评估胎儿耳廓对先天性外耳道闭锁的预测价值
- Author:
Youlu LIU
1
;
Ting LEI
1
;
Yuting JIANG
1
;
Ju ZHENG
1
;
Qiao ZHENG
1
;
Miao HE
1
;
Lihe ZHANG
1
;
Hongning XIE
1
Author Information
1. 中山大学附属第一医院超声医学科，广州 510080
- Publication Type:Journal Article
- Keywords:
Ultrasonography，prenatal;
Congenital aural atresia;
Auricular morphotyping;
Auricular dimensions
- From:
Chinese Journal of Ultrasonography
2025;34(2):155-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the value of prenatal three-dimensional ultrasonography（3DUS）in displaying auricular morphotyping and dimensions for predicting congenital aural atresia（CAA）.Methods:A retrospective collection of 227 fetuses who underwent ultrasound scans and retained auricular 3DUS volumes from January 2018 to December 2023 at the First Affiliated Hospital of Sun Yat-sen University was conducted. Fetuses were divided into two groups：a CAA group（52 fetuses，62 auricles）and a non-CAA group（175 fetuses，202 auricles），based on the presence or absence of external auditory canal identified through postnatal examination. According to 3DUS auricular contour and presence or absence of the concha，the auricles were divided into 4 types：type Ⅰ，C-shaped auricle with a concha；type Ⅱ，Irregular auricle with a concha；type Ⅲ，C-shaped auricle without a concha；type Ⅳ，Irregular auricle without a concha. And auricular length（AL）and width（AW）were measured to calculate the product of the auricular length and width（ALW）. Normal reference ranges for ALW from the non-CAA group were developed. Differences of the auricular morphotyping and Z-score of ALW（ALWZ）were compared between the two groups. Receiver operating characteristic（ROC）curves were used to evaluate the diagnostic efficiency of auricular morphotyping，ALWZ and the regression model. A Logistic regression model for CAA based on auricular morphotyping and ALWZ were established.Results:The auricular morphotyping and ALWZ between the two groups were different statistically（both P<0.05）. The AUC of the auricular morphotyping and ALWZ predicting CAA were 0.960（95% CI = 0.923 - 0.997）and 0.975（95% CI = 0.959 - 0.991）individually. Formula for CAA prediction model combining the two indicators（5.379 × morphotyping - 2.386 × ALWZ - Conclusions:The auricular morphotyping and dimensions can effectively predict CAA.
