Construction and implementation of an immunosuppressant administrating via feeding tubes scheme for lung transplantations
10.3761/j.issn.0254-1769.2025.07.008
- VernacularTitle:肺移植患者术后免疫抑制剂管饲给药方案的构建及初步应用
- Author:
Qionglin DENG
1
;
Wenbo QIAO
1
;
Junqing CHU
1
;
Yan LIN
1
;
Yayu REN
1
;
Xuehong ZHAO
1
Author Information
1. 310003杭州市 浙江大学医学院附属第一医院护理部
- Publication Type:Journal Article
- Keywords:
Lung Transplantation;
Immunosuppressant;
Medication Care;
Delphi Technology
- From:
Chinese Journal of Nursing
2025;60(7):819-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a scheme of immunosuppressant(tacrolimus)tube administration after lung transplantation and evaluate the effect.Methods Utilizing evidence summary and the Delphi method with the Structure-Process-Outcome(SPO)model,a tacrolimus administrating via feeding tubes scheme was established for lung transplantations,incorporating 5 aspects"medication management""risk assessment""enteral feeding implementation""process monitoring"and"evaluation and feedback"from July to September 2023.A convenience sampling method was employed to select patients with lung transplant surgery of a tertiary hospital in Zhejiang Province from November 2023 to June 2024.Among them,18 patients admitted from March to June 2024 were designated as an experimental group,receiving the developed tacrolimus enteral feeding administration plan;18 patients admitted from November 2023 to February 2024 were designated as a control group,receiving standard enteral feeding administration measures.The standard trough concentration of tacrolimus,the coefficient of variation of tacrolimus trough concentration,the daily dosage of tacrolimus and its coefficient of variation,and the rate of achieving the target trough concentration of tacrolimus were compared between the 2 groups.Results Of the initially recruited subjects,15 in the experimental group and 18 in the control group were included in the final analysis.After intervention,the coefficient of variation of trough concentrations and daily doses of tacrolimus in the experimental group were lower than those in the control group,while the rate of achieving target trough concentrations was higher,with all differences being statistically significant(P＜0.05).There was no statistically significant difference in the comparison of standardized blood drug concentrations and the coefficient of variation of daily doses between the 2 groups(P＞0.05).Conclusion The tacrolimus administrating via feeding tubes scheme for lung transplantations based on the SPO model is scientific and practical,providing clinical references for the use of tacrolimus enteral medication after lung transplantation,in order to promote the standardization of tacrolimus enteral administration.
