Research advances of pathological mechanisms, biomarkers and therapeutic strategies in Alzheimer′s disease
10.3760/cma.j.cn113694-20250428-00251
- VernacularTitle:阿尔茨海默病病理机制、生物标志物与治疗策略研究进展
- Author:
Mengqing GUO
1
;
Chenyang LI
;
Yingying WANG
;
Yiqing WANG
;
Guojie ZHAI
Author Information
1. 苏州大学附属苏州九院神经内科，苏州215200
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Pathological mechanism;
Biomarkers;
Therapy
- From:
Chinese Journal of Neurology
2025;58(12):1316-1323
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease (AD) is one of the most common neurodegenerative diseases. As the global population ages, incidence, morbidity and mortality of AD have increased significantly. The core pathological features of AD include β-amyloid (Aβ) deposition and phosphorylated tau aggregation, resulting in neuronal damage, abnormal mental behavior, and cognitive decline. In recent years, research breakthroughs have not only deepened the Aβ cascade hypothesis and the pathological theory of tau protein, but also made important progress in the fields of neuroimmune regulation, "microbiota-gut-brain" axis, genetic factors, especially the ApoEε4 allele. At the same time, AD has been continuously enriched in blood, cerebrospinal fluid and imaging markers, and sensitivity of markers has been improved and detection tends to be non-invasive. Therapeutic strategies for AD include traditional drugs, novel drugs targeting Aβ/tau protein, and non-pharmacological interventions such as cognitive training, non-invasive brain stimulation and exercise. This review systematically expounds the pathological mechanism, biomarkers, and treatment strategies of AD, aiming to provide a scientific basis for the establishment of a biomarker-based precision diagnosis and treatment paradigm.
