Role and potential mechanisms of lactylation modification in ischemic stroke
10.3760/cma.j.cn113694-20250522-00299
- VernacularTitle:乳酸化修饰在缺血性卒中发生中的作用及潜在机制
- Author:
Xinlei HUANG
1
;
Shanshan LIU
1
;
Hequn LYU
1
;
Yana CAO
1
;
Yongjun PENG
1
Author Information
1. 南京中医药大学附属医院针灸康复科，南京 210029
- Publication Type:Journal Article
- Keywords:
Lactylation;
Ischemic stroke;
Neuroinflammation;
Energy metabolism regulation;
Oxidative stress;
Signaling pathway regulation;
Angiogenesis
- From:
Chinese Journal of Neurology
2025;58(12):1351-1357
- CountryChina
- Language:Chinese
-
Abstract:
Lactylation, a newly discovered post-translational modification, has been reported to be involved in various physiological and pathological processes. Recent studies have found that lactylation is potentially linked to the pathological processes and repair mechanisms of ischemic stroke. This article explores the impact and role of lactylation after the occurrence of ischemic stroke on neuroinflammation, energy metabolism regulation, oxidative stress, signaling pathway modulation, and angiogenesis. It may serve as a bridge connecting lactylation and ischemic stroke, offering insights and guidance for future research and clinical strategies in ischemic stroke.
