Research advances in microglial lipid metabolism dysfunction in Alzheimer′s disease
10.3760/cma.j.cn113694-20250411-00202
- VernacularTitle:阿尔茨海默病的小胶质细胞脂质代谢障碍研究进展
- Author:
Yuchen ZHANG
1
;
Xiaoli HUANG
1
;
Ling XIE
1
Author Information
1. 温州医科大学，温州325035
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Lipids;
Microglia;
Lipid metabolism, inborn errors
- From:
Chinese Journal of Neurology
2025;58(10):1113-1118
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease (AD) is a neurodegenerative disorder primarily characterized by progressive memory decline and cognitive dysfunction. Lipid droplets (LDs) are dynamic organelles that store neutral lipids and play a crucial role in maintaining intracellular lipid homeostasis. Dysregulated lipid metabolism in microglia and its role in mediating abnormal LDs accumulation have been shown to significantly contribute to AD pathogenesis. This review summarizes the regulatory pathways of LDs metabolism in microglia in AD and discusses how lipid metabolic dysfunction exacerbates AD pathology. Furthermore, this review highlights key molecular mechanisms governing microglial lipid metabolism in AD and explores potential therapeutic strategies targeting lipid metabolism for AD intervention.
