Analysis on clinical features and prognostic factors in 68 adult hemophagocytic syndrome
10.3969/j.issn.1673-9701.2025.12.014
- VernacularTitle:68例成人噬血细胞综合征患者临床特征和预后分析
- Author:
Rongyao ZHANG
1
;
Yanqun SHEN
1
;
Yigang GUO
1
;
Zhangzhi LI
1
;
Lulu ZHANG
1
Author Information
1. 十堰市太和医院 湖北医药学院附属医院血液内科,湖北十堰 442000
- Publication Type:Journal Article
- Keywords:
Hemophagocytic syndrome;
Clinical features;
Prognostic analysis
- From:
China Modern Doctor
2025;63(12):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical features and prognostic factors of adult hemophagocytic syndrome(HPS).Methods The clinical data of 68 newly diagnosed patients with HPS who were hospitalized from December 2018 to December 2023 were retrospectively analyzed,and clinical features,treatment and prognostic factors of patients were analyzed.Results The median age of 68 patients was 49(17-75)years old,the most common cause was infection,40 cases(58.82％),and the most common clinical manifestation was fever,63 cases(92.6％).Of the 68 patients,12(17.65％)patients died and the median survival time was 32 months.Cox univariate analysis showed that the prognosis of adult HPS was affected by SF,epstein-barr virus(EBV)infection,platelet count(＜20× 109/L),age over 60 years old,activated partial thromboplastin over 60s and other factors(P＜0.05).Multivariate Cox analysis showed that EBV infection and platelet count(＜20×109/L)were independent prognostic factors of adult HPS(P＜0.05).Conclusion The clinical manifestations of adult HPS are not typical,and the prognosis of adult HPS is affected by many factors.EBV infection and platelet count(＜20× 109/L)are independent risk factors for death.
