Ancient data mining on drug characteristics of knee osteoarthritis
10.3969/j.issn.1673-9701.2025.12.001
- VernacularTitle:膝骨关节炎用药特点的古代数据挖掘
- Author:
Zihan MENG
1
;
Yueyue YU
;
Xiaoyi SHI
;
Xinyu MA
;
Dingding WU
;
Xu ZHANG
;
Heyi LI
;
Jingya WANG
;
Liyuan ZHANG
;
Heli ZHAO
Author Information
1. 华北理工大学中医学院,河北唐山 063210
- Publication Type:Journal Article
- Keywords:
Knee osteoarthritis;
Latent structure;
Association rule analysis;
Medication law
- From:
China Modern Doctor
2025;63(12):1-4,48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze ancient prescriptions for knee osteoarthritis(KOA),and explore their application patterns,for providing clinical reference value.Methods Prescriptions were collected from ancient documents,and a database was created by using Excel 2016 for frequency analysis.Association rules and hidden structures were analyzed by using SPSS Modeler 18.0 and Lantern 5.0.Results A total of 373 prescriptions and 421 herbs were collected,with 3894 times of frequency of medication.Danggui was the most frequently used herb.Herbs primarily tonified deficiencies,relieved exterior symptoms,and expelled wind-dampness,with warm properties and pungent,sweet,or bitter tastes,mainly targeting the spleen and kidney meridians.Thirteen strong association rules were identified,including Chuanxiong+Niuxi-Danggui,and Bixie-Niuxi.Hidden structure analysis revealed 10 variables,leading to 4 clusters and 4 core prescriptions.Common syndromes included wind-damp,wind-cold-damp,wind-damp-heat,and qi-blood deficiency.Conclusion The treatment of KOA in ancient literature focuses on dispelling wind and removing dampness,taking into account both positive deficiency and evil excess,flexible use of tonifying spleen and kidney,clearing dampness-heat,tonifying Qi and blood and other drugs.
