Therapeutic effect of Xuanfei Zhisou Mixture combined with ceftriaxone sodium in treatment of cough after infection
10.11816/cn.ni.2024-240407
- VernacularTitle:宣肺止嗽合剂联合头孢曲松钠治疗感染后咳嗽的疗效
- Author:
Lina MAO
1
;
Qingshan FANG
1
;
Guangwei LUO
1
Author Information
1. 武汉市中西医结合医院(武汉市第一医院)呼吸与危重症医学科,湖北武汉 430022
- Publication Type:Journal Article
- Keywords:
Acute respiratory tract infection;
Post infectious cough;
Xuanfei Zhisou Mixture;
Ceftriaxone sodium;
Toll-like receptor 4;
Nuclear factor-κB;
Signal pathway
- From:
Chinese Journal of Nosocomiology
2025;35(5):657-661
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the therapeutic effect of Xuanfei Zhisou Mixture combined with ceftriaxone so-dium in treating post-infectious cough with wind-evil invading lung syndrome and its effect on Toll-like receptor 4(TLR4)/nuclear factor-KB(NF-κB)signaling pathway.METHODS The clinical data of 100 patients with post-in-fectious cough admitted to Wuhan Hospital of Integrated Traditional Chinese and Western Medicine from Dec.2021 to Dec.2022 were retrospectively analyzed.According to different therapeutic schemes,the patients were di-vided into two groups:48 cases in the single-drug group and 52 cases in the combined group.The single-drug group was treated with ceftriaxone sodium,while the combined group was treated with Xuanfei Zhisou Mixture com-bined with ceftriaxone sodium.The total effective rate,traditional chinese medicine(TCM)symptom score,leicester cough quality of life questionnaire(LCQ),serum levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and inducible nitric oxide synthase(iNOS)]and TLR4/NF-κB signaling pathway expression were analysed to evaluate the therapeutic effect.RESULTS After treatment,the total effective rate of the combined group was higher than that of the single-drug group(94.23％vs.77.08％,x2=6.096,P=0.014);meanwhile,compared to the single-drug group,the TCM symptom score,TNF-α,IL-6,iNOS,TLR4,NF-κB levels,TLR4 protein and NF-κB protein expression in the combined group were significantly decreased(P＜0.05),and the LCQ score was significantly increased(P＜0.05).CONCLUSIONS Xuanfei Zhisou Mixture com-bined with ceftriaxone sodium has an obvious effect in treating post-infectious cough with wind-evil invading lung syndrome.They can effectively improve the cough symptoms and quality of life of patients and reduce the produc-tion of inflammatory factors by inhibiting TLR4/NF-κB signaling pathway.
