Application and Advances on Circulating Tumor DNA in Esophageal Cancer
10.11735/j.issn.1004-0242.2025.05.A009
- VernacularTitle:循环肿瘤DNA在食管癌诊疗中的应用及最新进展
- Author:
Yurong JIANG
1
;
Ziyu WANG
1
;
Rui LING
1
;
Chunhua DAI
1
Author Information
1. 江苏大学附属医院,江苏大学肿瘤研究院,江苏镇江 212002
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
circulating tumor DNA;
diagnosis;
treatment
- From:
China Cancer
2025;34(5):391-396
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer is one of the most prevalent malignant tumors globally.Its clinical management is challenged by difficulties in early diagnosis,significant inter-individual variability in therapeutic efficacy,and high rates of tumor residuals and recurrence.Circulating tumor DNA(ctDNA),a novel liquid biopsy biomarker,reflects tumor burden and genetic characteristics.It offers advantages such as non-invasiveness,repeatability,and real-time dynamic monitoring,pro-viding a promising approach for precision diagnosis and treatment of esophageal cancer.In recent years,ctDNA has shown remarkable progress in the early detection,efficacy prediction,prognos-tic assessment,and monitoring of tumor residuals and recurrence in esophageal cancer,emerging as an essential tool in the clinical management of the disease.This review summarizes the latest advancements in ctDNA research in esophageal cancer,providing valuable insights and inspiration for future studies and clinical applications.
