Distinct gut microbiota and metabolic profiles in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease
10.3760/cma.j.cn113694-20250618-00358
- VernacularTitle:视神经脊髓炎谱系疾病及抗髓鞘少突胶质细胞糖蛋白抗体相关疾病患者的肠道菌群与代谢物差异研究
- Author:
Xiaowei PANG
1
;
Lian CHEN
;
Lan ZHANG
;
Shu FAN
;
Yuxin LIU
;
Wei WANG
;
Daishi TIAN
;
Chuan QIN
Author Information
1. 华中科技大学同济医学院附属同济医院神经内科 华中科技大学神经损伤与功能重建湖北省重点实验室，武汉 430030
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Neuromyelitis optica spectrum disorder;
Myelin oligodendrocyte glycoprotein antibody-associated disease;
Gut microbiota;
Metabolites
- From:
Chinese Journal of Neurology
2025;58(11):1160-1168
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the gut microbiota and metabolic profiles of patients with neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and to identify potential microbial biomarkers with diagnostic values.Methods:A total of 16 NMOSD patients, 6 MOGAD patients, and 22 age- and sex-matched healthy controls were recruited from Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology since June 2024. Fecal samples were subjected to metagenomic sequencing and untargeted metabolomics. Differential microbes were identified using LEfSe (linear discriminant analysis effect size), and receiver operating characteristic curve analysis was performed to evaluate diagnostic potential. Spearman correlation analysis was used to assess relationships between key microbes, metabolites, and serum antibody titers.Results:Distinct alterations in gut microbiota were observed in both disease groups compared with healthy controls. Ligilactobacillus salivarius was significantly enriched in both NMOSD and MOGAD patients and exhibited robust diagnostic accuracy (area under the curve=0.779 P=0.005). Metabolomics revealed that levels of ethosuximide and lysine-proline were elevated, while free fatty acids (15∶1) and 5, 6-dihydrothymine were reduced in the disease groups. Analysis results indicated that Ligilactobacillus salivarius abundance was positively correlated with aquaporin 4 antibody titers in NMOSD patients ( r=0.522, P=0.046). Conclusions:Patients with NMOSD and MOGAD have characteristic alterations in gut microbial and metabolic profiles.
