Dynamic changes of lymphocyte subsets in a patient with anti-N-methyl-D-aspartate receptor encephalitis overlaping with myelin oligodendrocyte glycoprotein antibody-associated diseases
10.3760/cma.j.cn113694-20241128-00769
- VernacularTitle:抗N-甲基-D-天冬氨酸受体脑炎叠加髓鞘少突胶质细胞糖蛋白抗体相关疾病患者的淋巴细胞亚群长期动态观察
- Author:
Li LI
1
;
Hongzhi GUAN
1
;
Siyuan FAN
1
;
Le ZHANG
1
;
Mange LIU
1
;
Lin BAI
1
;
Haitao REN
1
Author Information
1. 中国医学科学院北京协和医院神经科，北京100730
- Publication Type:Journal Article
- Keywords:
Anti-NMDAR encephalitis;
Myelin-oligodendrocyte glycoprotein;
Rituximab;
CD19
- From:
Chinese Journal of Neurology
2025;58(7):750-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the dynamic alterations of immune cell subsets in a patient with autoimmune encephalitis and the clinical relapses.Methods:For a patient with multiple relapses of anti-N-methyl-D-aspartate receptor encephalitis superimposed with myelin oligodendrocyte glycoprotein antibody-associated disease who visited Peking Union Medical College Hospital on July 18, 2018, the lymphocyte subsets were monitored dynamically over a long period and the relationship between lymphocyte subsets and the relapses was summarized.Results:The 38-year old male patient experienced a total of 5 episodes (including 4 relapses) during the six-year immunotherapy and follow-up process, and responded well to first-line and maintenance immunotherapy. His relapses occurred during drug reduction. Finally, the neurological symptoms resolved after rituximab treatment. A total of 39 tests of peripheral blood lymphocyte subsets were conducted during the follow-up, and 5 peaks of elevated CD19 positive B cells, 9 peaks of elevated CD3 positive T cells and 11 peaks of elevated natural killer cells were observed. The peak period of peripheral blood CD19 positive B cells exactly coincided with clinical relapses. While the consistency rates of clinical relapse and the peaks of peripheral blood CD3 positive T cells and natural killer cells were 5/9 and 2/11, respectively.Conclusions:The dynamic alterations of CD19 positive B cells in peripheral blood are correlated with the clinical relapse of autoimmune encephalitis and can predict clinical relapse.
