The immune microenvironment and immunotherapy in amyotrophic lateral sclerosis
10.3760/cma.j.cn113694-20250603-00329
- VernacularTitle:肌萎缩侧索硬化的免疫微环境与免疫治疗
- Author:
Xinyu YANG
1
;
Sen HUANG
1
;
Xiaoli YAO
1
Author Information
1. 中山大学附属第一医院神经科 广东省重大神经疾病诊治研究重点实验室 国家临床重点专科和国家重点学科，广州510080
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis;
Immunologic factors;
Immune microenvironment;
Immunotherapy
- From:
Chinese Journal of Neurology
2025;58(8):899-906
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease involving upper and lower motor neurons. Neuroinflammation is a common pathological feature of many neurodegenerative diseases and is characterized by inflammatory activation of microglia and astrocytes in the central nervous system (CNS) as well as CNS infiltration of peripheral macrophages and T cells. It has been shown that ALS-associated gene mutations enhance neuroinflammation and lead to dysregulation of the immune microenvironment. Therefore, this review provides an overview around the regulation of the immune microenvironment of ALS by various inflammatory cytokines and immune cells, as well as relative immunotherapies, aiming to provide a comprehensive understanding of ALS from an immune perspective.
