Research progress of meningeal lymphatic vessels in Alzheimer′s disease
10.3760/cma.j.cn113694-20250214-00086
- VernacularTitle:脑膜淋巴管在阿尔茨海默病中的研究进展
- Author:
Zijian CHEN
1
;
Yiming LIU
1
Author Information
1. 山东大学齐鲁医院神经内科，济南 250012
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Meningeal lymphatic vessels;
Lymphatic drainage;
Spatial variation;
Therapeutic interventions
- From:
Chinese Journal of Neurology
2025;58(9):995-1002
- CountryChina
- Language:Chinese
-
Abstract:
As an important structure for maintaining the homeostasis of the central nervous system, the meningeal lymphatic vessels can clear abnormal proteins and metabolic wastes from the brain. Numerous studies have shown that meningeal lymphatic vessel dysfunction is closely related to the pathological process of Alzheimer′s disease. Enhancing the drainage function of meningeal lymphatic vessels may provide an innovative strategy for the treatment of the disease. This article systematically expounds the structure, function and "space-dependent differences" of meningeal lymphatic vessels, deeply explores their role in the pathogenesis of Alzheimer′s disease, and investigates the intervention measures to improve the function of meningeal lymphatic vessels, aiming to open up new ideas for the prevention and treatment of Alzheimer′s disease.
