Advances in diagnostic imaging markers of Alzheimer′s disease

VernacularTitle:阿尔茨海默病诊断影像学标志物研究新进展
Author: Ziyun WANG ¹ ; Liu YANG ; Guowen MIN ; Yuyuan HUANG ; Jintai YU
Author Information

1. 复旦大学附属华山医院神经内科　国家神经疾病医学中心，上海200040
Publication Type:Journal Article
Keywords: Alzheimer disease; Imaging biomarkers; Molecular imaging; Precision medicine
From: Chinese Journal of Neurology 2025;58(8):892-898
CountryChina
Language:Chinese
Abstract: Alzheimer′s disease (AD) is one of the most common neurodegenerative diseases, and its diagnosis heavily relies on imaging biomarkers. This paper integrates core pathological markers, such as amyloid β (Aβ)-positron emission tomography (PET), tau-PET, structural magnetic resonance imaging, and fluorodeoxyglucose-PET, with the latest advancements in novel imaging biomarkers, including inflammation, synaptic imaging, and cerebrovascular injury-related markers, based on the Aβ proteinopathy, tau proteinopathy, neurodegeneration, inflammation, α-synuclein and vascular brain injury biomarkers (AT 1T 2NISV) framework proposed by the 2024 Alzheimer′s Association diagnostic guidelines. With the development of machine learning and artificial intelligence technologies, future research should focus on enhancing the specificity of imaging biomarkers and developing precise diagnostic models for comorbidities to better address the heterogeneity and complex pathological features of AD.