A case of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia
10.3760/cma.j.cn113694-20241008-00656
- VernacularTitle:抗Ca/ARHGAP26抗体相关自身免疫性小脑共济失调1例
- Author:
Ming QU
1
;
Li FENG
1
Author Information
1. 中南大学湘雅医院神经内科 国家老年疾病临床医学研究中心，长沙410008
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases of the nervous system;
Cerebellar ataxia;
Anti-Ca/ARHGAP26 antibody
- From:
Chinese Journal of Neurology
2025;58(5):536-539
- CountryChina
- Language:Chinese
-
Abstract:
A case of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia was reported in this article. The patient presented with cerebellar ataxia, including dizziness, unsteady gait, and slurred speech. Enhanced magnetic resonance imaging+diffusion-weighted imaging showed suspicious fluid attenuated inversion recovery (FLAIR) hyperintensities in the cerebellum, and the 18 000 translocator protein (TSPO)-positron emission tomography revealed increased uptake in the cerebellum and brainstem. Both cerebrospinal fluid and serum were positive for anti-Ca/ARHGAP26 antibodies. The patient′s symptoms improved after glucocorticoid, lymphoplasmapheresis, and immunotherapy treatments. Immune maintenance therapy post-discharge led to continued improvement over 7 months. TSPO imaging and immune antibody testing were utilized in this case for diagnosis, marking a significant clinical diagnostic attempt for this condition.
