Effect of hyperbaric oxygen therapy on serum neuron-specific enolase in patients with moderately severe to profound sudden deafness
10.3760/cma.j.cn311847-20211219-00350
- VernacularTitle:高压氧治疗对中重度至极重度突发性聋患者血清神经元特异性烯醇化酶的影响
- Author:
Yi ZHANG
1
;
Xingyuan JIA
;
Yan ZHOU
;
Xuehua LIU
;
Fang LIANG
;
Lin ZHAO
;
Yu GAO
;
Jing YANG
Author Information
1. 首都医科大学附属北京朝阳医院高压氧科，北京 100020
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Idiopathic sudden sensorineural hearing loss;
Neuron-specific enolase
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(3):340-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the changes in serum neuron-specific enolase（NSE）in patients with moderately severe to profound idiopathic sudden sensorineural hearing loss（ISSHL）and the effect of hyperbaric oxygen（HBO）therapy on NSE，and to analyze the relationship between hearing recovery and serum NSE levels.Methods:Using convenient sampling，a total of 90 inpatients with unilateral moderately severe to profound ISSHL were selected as the research subjects，and they were divided into observation group and control group according to the random number table method，with 45 cases in each group. The control group received hormones，Ginkgo biloba injection，and neurotropic drugs，and the observation group was treated with HBO based on the treatment of the control group. Pure tone audiometry was performed before and after treatment to test hearing levels，and serum NSE was determined by ELISA. After 20 days of treatment，the effective rates and the changes of NSE of the two groups were compared，and the relation between NSE level and hearing change were analyzed.Results:The serum NSE levels of ISSHL patients in both groups were significantly higher than those of the control group，and it was correlated with the severity of hearing loss（ P<0.01）. The serum NSE levels of profound ISSHL patients were significantly higher than those of moderately severe and severe ISSHL patients（ P<0.01）. After treatment，the clinical effective rate of the observation group（82.2%）was significantly higher than that of the control group（60.0%）（ P<0.05）；the hearings of the patients in both groups were significantly improved compared with those before treatment；the pure tone average of the observation group was lower than that of the control group（ P<0.05）；and the hearing threshold gain of the observation group was significantly higher than that of the control group（ P<0.01）. After treatment，the NSE levels of the patients in the two groups decreased after treatment；the NSE level of the observation group was significantly lower than that of the control group（ P<0.05）；and the decrease of NSE level in the observation group was significantly greater than that of the control group（ P<0.01）. The decreases of serum NSE in the two groups were positively correlated with the gains of the auditory domain（ r=0.686， P<0.01 in the observation group； r=0.418， P<0.01 in the control group）. Conclusion:The serum NSE level of patients with moderately severe to profound ISSHL is increased，which is related to the severity of hearing loss. Additionally adopting HBO therapy could improve the hearing of patients，increase the effective rate，and reduce the NSE level of ISSHL patients.
