Treatment of trigeminal neuralgia with botulinum toxin type A and cobrotoxin: a case report

VernacularTitle:联合A型肉毒毒素及眼镜蛇神经毒素治疗三叉神经痛1例
Author: Yingying XU ¹ ; Shuyang MA ; Ying LI ; Jili BAO ; Zhou XU ; Chengwei GUO ; Jing LIU ; Weifeng LUO
Author Information

1. 苏州大学附属第二医院神经内科，苏州　215004
Publication Type:Journal Article
Keywords: Trigeminal neuralgia; Botulinum toxins; Cobrotoxin
From: Chinese Journal of Neurology 2025;58(4):426-429
CountryChina
Language:Chinese
Abstract: Trigeminal neuralgia is characterized by intense pain in the sensory distribution area of the trigeminal nerve. It can be triggered by non-noxious stimuli such as brushing teeth and washing face. At present, the treatment of trigeminal neuralgia mainly includes oral drugs and surgical treatments. A 92-year-old patient with trigeminal neuralgia was reported. The pain could not be alleviated because the patient was unable to tolerate the side effects of drugs and surgical treatment. Taking into account the onset time and the duration of the curative effect, botulinum toxin type A was combined with cobrotoxin for the treatment of the patient. As a result, the pain symptoms were rapidly alleviated and remained in a relieved state for 8 months. The clinical characteristics of this patient were summarized in this article, and the possible synergistic mechanisms of action of the 2 drugs were discussed. The ultimate objective is to furnish a broader spectrum of alternatives and references for clinical practice.