Effects of electromagnetic radiation on the nervous system in rats
10.3760/cma.j.cn311847-20211216-00345
- VernacularTitle:电磁辐射对大鼠神经系统的影响
- Author:
Jianping ZHANG
1
;
Shuanghong CHEN
;
Guozhen GUO
;
Hongyuan ZHOU
;
Peng GAO
;
Xiaomeng REN
Author Information
1. 海军军医大学海军特色医学中心，上海 200433
- Publication Type:Journal Article
- Keywords:
Electromagnetic radiation;
Cholinergic neurotransmitters;
Blood-brain barrier，Hsp70
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(3):367-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of electromagnetic radiation（EMR）on the nervous system of rats in a simulated warship environment，so as to provide reference for improving the working condition for deck crew.Methods:A total of 36 adult male SD rats were randomly divided into six groups，with six rats in each group. There were four exposure groups：60 V/m exposure for 1 d and 3 d，120 V/m exposure for 1 d and 3 d. There were two control groups：control group for 1 d and control group for 3 d. After exposure，cholinergic neurotransmitters，blood-brain barrier permeability，and HSP70 were detected.Results:The content of ACh in hippocampus in the 60 V/m exposure for 3 d group［（515.52±5.88）pmol/L］was lower than that in the control group for 3 d［（550.94±20.44）pmol/L］，with statistically significant difference（ P<0.05）. The contents of ACh in cerebral cortex in the 60 V/m exposure for 1 d group［（578.84±25.14）pmol/L］and the 120 V/m exposure for 1 d group［（519.62±13.09）pmol/L］were both lower than that in the control group for 1 d［（605.13±17.99）pmol/L］，with statistically significant differences（ P<0.05； P<0.01）. The contents of ACh in cerebral cortex in 60 V/m exposure for 3 d group［（586.20±12.20）pmol/L］and the 120 V/m exposure for 3 d group［（591.22±9.78）pmol/L］were both lower than that in the control group for 3 d［（623.68±15.07）pmol/L］，with statistically significant differences（ P<0.01）. The contents of AChE in hippocampus and cerebral cortex were significantly increased in all four exposure groups compared with their correspondent control groups（ P<0.01），respectively；the concentrations of S100β in serum were significantly increased in the exposure for 3 d groups（ P<0.01）；after radio frequency（RF）exposure，the positive expressions of Hsp70 increased rapidly. Conclusion:After 1 day or 3 days of S-band RF exposure with electric field intensities of 60 V/m and 120 V/m，the cholinergic neurotransmitters in the brains of SD rats have changed，the permeability of blood-brain barrier is increased，and the positive expressions of Hsp70 are increased. It is speculated that S-band RF exposure can affect neurological system of SD rats，suggesting that the EMR of this band can bring potential harm to the deck crew，which demands appropriate protective measures.
