The role of the cerebellum in the onset and progression of Parkinson′s disease
10.3760/cma.j.cn113694-20240827-00584
- VernacularTitle:帕金森病发病及进展过程中小脑的作用
- Author:
Mengshi LIAO
1
;
Yuhu ZHANG
1
Author Information
1. 南方医科大学附属广东省人民医院（广东省医学科学院）神经科 广东省神经科学 研究所 广州市神经退行性疾病诊治研究重点实验室，广州 510080
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Cerebellum;
Neural circuits;
Neurotransmitters;
Pathophysiology
- From:
Chinese Journal of Neurology
2025;58(3):320-325
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor dysfunction, with its pathophysiology mainly involving the basal ganglia-thalamocortical pathway. In recent years, the role of cerebellar neural networks in PD has garnered increasing attention. The cerebellum not only plays a role in motor control but also influences non-motor functions such as cognition and emotion. Through its extensive connections with the basal ganglia and cerebral cortex, the cerebellum is critically involved in regulating neural networks in PD. This review summarizes the structural and functional changes of the cerebellum in PD patients, as well as the pathophysiological interactions between cerebellar networks and the basal ganglia-thalamocortical pathway, which collectively impact both motor and non-motor functions in PD. The aim of the review is to provide a new perspective on the role of the cerebellum in the pathogenesis of PD.
