Analysis of the effects of hyperbaric oxygen as adjuvant therapy on primary nephrotic syndrome and renal function
10.3760/cma.j.cn311847-20211015-00277
- VernacularTitle:高压氧辅助治疗原发性肾病综合征的疗效及对肾功能的影响
- Author:
Yan ZHUANG
1
;
Jiaqiang LIU
Author Information
1. 临沂市中心医院肾内科，临沂 276400
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Primary nephrotic syndrome;
Renal function
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(3):336-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effects of hyperbaric oxygen（HBO）as adjuvant therapy on primary nephrotic syndrome（PNS）and renal function.Methods:A total of 92 PNS patients admitted to the Linyi Central Hospital from January 2020 to June 2021 were selected and divided into control group（ n=46）and observation group（ n=46）according to different treatment methods. The control group was given conventional treatment，and the observation group was given HBO on this basis of the treatment in the control group. The changes in the blood lipid-related indexes，inflammatory factor levels，and renal function in the two groups were compared before and after treatment，and the incidence of complications and the clinical therapeutic effect after treatment were observed. Results:Before treatment，there were no significant difference in blood lipid-related indexes，inflammatory factor levels，or renal function indexes between the two groups. After treatment，the above-mentioned indexes in both groups were all improved. The levels of cholesterol（CHOL），triglyceride（TG），and the inflammatory factors including IL-1，IL-6，and TNF-α in the observation group were significantly lower than those in the control group（ P<0.05）. The total effective rate in the observation group［93.48%（43/46）］was higher than that in the control group［76.09%（35/46）］，with statistically significant difference（ P<0.05）. The incidence of complications in the observation group［4.35%（2/46）］was significantly lower than that in the control group［19.57%（9/46）］，with statistically significant difference（ P<0.05）. After treatment，the serum creatinine，urea nitrogen，and 24-hour urinary protein quantification in the observation group were lower than those in the control group，and the serum albumin level in the observation group was higher than that in the control group，and all the differences were statistically significant（ P<0.05）. Conclusion:HBO as adjuvant therapy can improve the clinical therapeutic effect and enhance renal function，by effectively reducing the blood lipid level and inflammatory response and reducing complications，which is worth further popularization in clinical practice.
