Effect of hyperbaric oxygen combined with rosuvastatin on the clinical efficacy，levels of serum inflammatory factors，and hemorheological parameters in patients with T2DM combined with coronary heart disease
10.3760/cma.j.cn311847-20210927-00261
- VernacularTitle:高压氧联合瑞舒伐他汀治疗对2型糖尿病合并冠心病患者疗效、血清炎性因子及血液流变学的影响
- Author:
Bin CHEN
1
;
Hui ZHAO
;
Chenghua LIU
;
Hailiang YU
Author Information
1. 临沂市中心医院心血管内科，临沂 276400
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Rosuvastatin;
Type 2 diabetes mellitus（T2DM）;
Coronary heart disease;
Serum inflammatory factors
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(3):331-335
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of hyperbaric oxygen（HBO）combined with rosuvastatin on the levels of D-dimer（D-D），lipoprotein-associated phospholipase A2（Lp-PLA2），and high-sensitivity C-reactive protein（hs-CRP）in patients with type 2 diabetes mellitus（T2DM）combined with coronary heart disease（CHD）.Method:The clinical data of 167 T2DM patients combined with CHD admitted to Linyi Central Hospital from July 2019 to July 2021 were retrospectively analyzed. They were divided into two groups according to different treatment methods. The control group（ n=78）was given conventional treatment and oral rosuvastatin，and the study group（ n=89）was treated with HBO on the basis of the treatment in the control group. The effective rate，blood viscosity，and the levels of D-D，Lp-PLA2，and hs-CRP were compared between the two groups. Results:After treatment，the effective rate in the study group［93.23%（83/89）］was significantly higher than that of the control group［82.05%（64/78）］，and the difference was statistically significant（ P<0.05 or P<0.01）；the serum levels of D-D，Lp-PLA2，hs-CRP，and blood viscosity in the study group were significantly lower than those of the control group，and the differences were statistically significant（ P<0.05 or P<0.01）. Conclusion:HBO combined with rosuvastatin in the treatment of T2DM patients combined with CHD can be more effective than using rosuvastatin alone in reducing D-D，Lp-PLA2，hs-CRP levels，and blood viscosity，thus achieving better clinical efficacy.
