Analysis of clinical efficacy and prognostic risk factors of emergency bundle combined with hyperbaric oxygen therapy for patients with carbon monoxide poisoning
10.3760/cma.j.cn311847-20201201-00454
- VernacularTitle:急诊集束化联合高压氧治疗对一氧化碳中毒患者的临床疗效及其预后危险因素分析
- Author:
Lianbin ZHAO
1
;
Guihu DU
1
;
Yujing WU
1
Author Information
1. 临沂市中心医院急诊科，临沂 276400
- Publication Type:Journal Article
- Keywords:
Carbon monoxide poisoning;
Hyperbaric oxygen;
Emergency bundle;
Risk factor
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2022;29(3):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of emergency bundle combined with hyperbaric oxygen therapy for patients with carbon monoxide poisoning and to analyze prognostic risk factors.Methods:A total of 116 patients with carbon monoxide poisoning treated in Linyi Central hospital from February 2015 to May 2020 were selected retrospectively and divided into control group and treatment group according to different treatment methods，with 58 cases in each group. The control group was treated with hyperbaric oxygen，and the treatment group was treated with emergency bundle on the basis of the treatment of the control group. The clinical efficacy of the two groups were observed and compared.Results:The total effective rate of the treatment group（93.10%）was significantly higher than that of the control group（77.59%），and the difference was statistically significant（ P<0.05）. There was no significant difference in respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）between two groups before treatment（ P > 0.05）. After treatment，the respiratory rate（RR），arterial partial pressure of oxygen（PaO 2），and blood oxygen saturation（SaO 2）were improved in two groups compared with those before treatment，and the treatment group was better than the control group，with statistical significance（ P < 0.05 or P < 0.01）. The coma time（≧24 h），abnormal EEG，hyperbaric oxygen treatment time（≧7 d），abnormal head CT and CO exposure time（≧3 h）in two groups were the main factors affecting the prognosis of CO poisoning（ P < 0.01）. Furthermore，coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning（ P < 0.05 or P < 0.01）. Conclusion:Emergency bundle combined with hyperbaric oxygen therapy has a good clinical effect on patients with carbon monoxide poisoning. It can effectively improve the SaO 2 and PaO 2 of patients. The coma time，hyperbaric oxygen treatment time，and abnormal head CT were the risk factors affecting the prognosis of CO poisoning.
