Amyloid deposition in skeletal muscle and amyloid myopathy in systemic amyloidosis
10.3760/cma.j.cn113694-20240828-00585
- VernacularTitle:系统性淀粉样变性中骨骼肌淀粉样物质沉积与淀粉样变性肌病
- Author:
Jingwen XU
1
;
Chuanzhu YAN
1
Author Information
1. 山东大学齐鲁医院神经内科 山东省罕见病线粒体医学重点实验室，济南250012
- Publication Type:Journal Article
- Keywords:
Amyloidosis;
Muscle, skeletal;
Neuromuscular diseases
- From:
Chinese Journal of Neurology
2025;58(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
Systemic amyloidosis is a disease caused by the deposition of misfolded proteins that often affects multiple organs, including the heart and kidneys, etc . Amyloid myopathy is one of the manifestations, but it has been considered rare. However, recent studies have found amyloid deposition in skeletal muscle even in patients with neither muscle weakness nor creatine kinase elevation, suggesting that skeletal muscle involvement may be underestimated. At present,"amyloid myopathy" lacks clear diagnostic criteria, and amyloid deposition in skeletal muscle does not always accompany myopathy symptoms, so "skeletal muscle amyloidosis" may be a more appropriate diagnosis. The exact mechanism of muscle injury caused by amyloid deposition in skeletal muscle is not clear, and may be involved in the scope of amyloid involvement, amyloidosis peripheral neuropathy, and immune activation.
