Clinical seizures and subclinical epileptiform activity in dementia with Lewy bodies
10.3760/cma.j.cn113694-20241028-00699
- VernacularTitle:路易体痴呆中癫痫及亚临床癫痫活动研究进展
- Author:
Ying XU
1
;
Guili ZHANG
;
Qun WANG
Author Information
1. 首都医科大学附属北京天坛医院神经病学中心 国家神经系统疾病临床医学研究中心，北京 100070
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Seizures;
Electroencephalography;
Dementia with Lewy bodies;
Subclinical seizure
- From:
Chinese Journal of Neurology
2025;58(1):109-115
- CountryChina
- Language:Chinese
-
Abstract:
Dementia with Lewy bodies (DLB) is the second most prevalent type of dementia among neurodegenerative disorders. The latest guideline for diagnosis and treatment of DLB in China has defined electroencephalography abnormalities as one of the supportive biomarkers. Seizures and epileptiform discharges in patients with DLB are gradually attracting attention and research, and there is increasing evidence of the correlation between DLB and epilepsy. However, the identification and diagnosis of seizures in DLB patients are challenging. In addition to clinical seizures, subclinical epileptiform activity is also an important part in DLB research. The underlying pathological mechanism of DLB epileptic seizures is still unclear. The current connection, potential pathological mechanisms, and possible future research directions between epilepsy and DLB were summarized in this review. The current relationship between epilepsy and DLB, potential pathological mechanisms and possible future research directions were summarized in this review, reminding clinicians to pay attention to the epilepsy and subclinical epilepsy activity in the diagnosis and treatment process, early identification, and timely intervention of the DLB patients.
