Analysis of clinical characteristics of heart failure with perserved ejection fraction patients with normal NT-proBNP
10.3969/j.issn.1673-9701.2025.29.006
- VernacularTitle:NT-proBNP正常的射血分数保留型心力衰竭患者的临床特征分析
- Author:
Mingze WANG
1
;
Kaile WANG
;
Changjun LYU
;
Xiaoli LIU
Author Information
1. 滨州医学院附属医院呼吸与危重症医学科,山东滨州 256600;滨州医学院研究生学院,山东滨州 256600
- Publication Type:Journal Article
- Keywords:
Heart failure with preserved ejection fraction;
N-terminal pro-brain natriuretic peptide;
Echocardiographic parameters
- From:
China Modern Doctor
2025;63(29):23-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of heart failure with preserved ejection fraction(HFpEF)patients with normal N-terminal pro-brain natriuretic peptide(NT-proBNP).Methods A total of 116 HFpEF patients diagnosed at Binzhou Medical University Hospital form January 2022 to October 2024,along with 61 non-heart failure patients were selected as subjects.Using NT-proBNP diagnosis criteria,HFpEF patients were divided into normal NT-proBNP group(n=62)and elevated NT-proBNP group(n=54),with non-heart failure patients serving as control group(n=61).Clinical parameters including laboratory tests,echocardiography,and CT imaging were systematically compared among all three groups to characterize the clinical features of HFpEF patients with normal NT-proBNP.Results Compared with elevated NT-proBNP group,prevalence of complications,such as hypertension,diabetes,and atrial fibrillation and pulmonary hypertension incidence were lower in normal NT-proBNP group significantly.Left ventricular diastolic function indicators was superior in normal NT-proBNP group than that in elevated NT-proBNP group,with significant differences(P＜0.05).Imaging evaluations revealed that chest CT scans of the normal NT-proBNP group more frequently exhibited characteristic ground-glass opacities.Conclusion HFpEF patients with normal NT-proBNP display distinct clinical characteristics,including milder cardiac structural abnormalities,lower comorbidity burden,and unique imaging manifestations such as ground-glass opacities,which can provide reference for early clinical diagnosis.
