Longitudinal stability of clinically used neuropsychological scales: a cross-sectional study
10.3760/cma.j.cn113694-20241024-00689
- VernacularTitle:临床常用神经心理量表的纵向稳定性：一项横断面研究
- Author:
Yuyue QIU
1
;
Wei JIN
;
Li SHANG
;
Shanshan CHU
;
Tianyi WANG
;
Yuhan JIANG
;
Jialu BAO
;
Wenjun WANG
;
Bo LI
;
Yixuan HUANG
;
Liling DONG
;
Chenhui MAO
;
Jianyong WANG
;
Jing GAO
Author Information
1. 中国医学科学院北京协和医学院北京协和医院神经科 疑难重症及罕见病国家重点实验室，北京 100730
- Publication Type:Journal Article
- Keywords:
Neuropsychological tests;
Dementia;
Mini-Mental State Examination;
Montreal Cognitive Assessment;
Activity of Daily Living Scale
- From:
Chinese Journal of Neurology
2025;58(1):17-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the longitudinal stability of the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and the Activity of Daily Living Scale (ADL).Methods:The longitudinal cognitive assessment results of 68 dementia patients admitted to the Dementia and Leukoencephalopathy Outpatient Clinic, Department of Neurology, Peking Union Medical College Hospital, from January 2021 to January 2024, were retrospectively analyzed, including the total and sub-items scores of the MMSE, MoCA, and ADL. Two different rules were applied to analyze the abnormality rates: rule 1, where the current test result being better than the previous one was considered an abnormality; rule 2, where the current test result being better than the previous average score was considered an abnormality (If a patient had only 2 cognitive assessments, rule 2 was considered the same as rule 1). Two rules were used to analyze the abnormality rates of the scales. The statistical analyses were repeated after excluding patients with possible anxiety and depression status.Results:In assessing the total score stability, MMSE showed the lowest abnormality rates [27.2% (31/114) under rule 1 and 29.8% (34/114) under rule 2], while MoCA had the highest abnormality rates [41.3% (26/63) and 46.0% (29/63), respectively]. The ADL abnormality rates were 27.7% (23/83) and 33.7% (28/83), respectively. Among MoCA sub-items, category cue, multiple choice cue, second memory trial, orientation, and clock showed higher abnormality rates [31.7%(20/63), 30.2%(19/63), 23.8%(15/63), 22.2%(14/63), 22.2%(14/63), respectively]. After excluding population with possible anxiety and depression status, the relative abnormality rates of MMSE and ADL sub-items did not significantly change, while the abnormality rate of orientation in MoCA sub-items decreased relatively.Conclusion:The MMSE and ADL exhibit good stability in long-term monitoring of dementia patients, serving as essential tools for assessing and following up cognitive changes.
