The opportunities and challenges on prevention and control of Alzheimer′s disease

VernacularTitle:阿尔茨海默病防治研究面临的机遇与挑战
Author: Heng ZHANG ¹ ; Chengxuan QIU ; Yifeng DU
Author Information

1. 山东第一医科大学附属省立医院神经内科，济南250021
Publication Type:Journal Article
Keywords: Alzheimer disease; Prevention; Treatment; MIND-CHINA
From: Chinese Journal of Neurology 2025;58(1):10-16
CountryChina
Language:Chinese
Abstract: Alzheimer′s disease (AD) is a major public health challenge with no curative treatment at present and has become the fifth leading cause of death for urban and rural residents in China. Although diagnostic technology has made significant progress in recent years, precise identification of AD still faces certain limitations and challenges due to its heterogeneity and complex pathogenesis. It is possible to shift the paradigm and focus on the key "window" of the early stage of AD dementia to achieve breakthroughs. This article is based on MIND-CHINA (randomized controlled Multimodal INterventions to delay Dementia and disability in rural China) to discuss the etiology, prediction, risk-factors assessment, diagnosis, and intervention research of AD, in order to develop AD prediction and prevention strategies that are in line with China′s national conditions, and make a multi-perspective analysis of the current limitations and challenges on AD diagnosis and prevention to promote the future of precision medicine for AD.