Discussion on the Correlation between"Mitochondrial Energy Metabolism-Intestinal Flora"and Chronic Heart Failure Based on the Theory of"Spleen-Small Intestine-Heart"Axis
10.19879/j.cnki.1005-5304.202411016
- VernacularTitle:基于"脾-小肠-心"轴理论探讨"线粒体能量代谢-肠道菌群"与慢性心力衰竭相关性
- Author:
Xiaowen ZHENG
1
;
Junping ZHU
;
Chengxin LIU
;
Min SHI
;
Qinghua ZENG
;
Zhihua GUO
;
Jiaming WEI
Author Information
1. 湖南中医药大学中医学院,湖南 长沙 410208
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
spleen-small intestine-heart axis;
intestinal flora;
mitochondrial energy metabolism
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(11):19-24
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure(CHF)is a common end-stage manifestation of cardiovascular disease,and the"spleen-small intestine-heart"axis is its important mechanism.Current studies have shown that the"spleen"in TCM and mitochondria function are similar,and the physiological dysfunction of the"small intestine"is also closely related to intestinal bacterial dysbiosis,and the pathology of the spleen and the small intestine will be transmitted to the heart to accelerate the occurrence and development of CHF.Based on the relevant theory of spleen-small intestine-heart,this article described the correlation between abnormal mitochondrial energy metabolism and imbalance of intestinal flora and CHF from the aspects of the spleen,small intestine and heart,and believed that the essence of CHF is a pathological condition formed by mitochondrial energy metabolism crisis and intestinal microecological disorders,which could provide theoretical references for the TCM prevention and treatment of CHF.
