Advances in rapid antimicrobial susceptibility testing for clinical laboratories
10.3760/cma.j.cn114452-20250219-00092
- VernacularTitle:临床实验室快速药敏试验研究进展
- Author:
Miao WANG
1
;
Jiancheng XU
1
Author Information
1. 吉林大学第一医院检验科，长春 130021
- Publication Type:Journal Article
- Keywords:
Microbiology;
Drug resistance, microbial;
Clinical laboratory techniques;
Microbiological techniques;
Microbial sensitivity tests
- From:
Chinese Journal of Laboratory Medicine
2025;48(9):1235-1241
- CountryChina
- Language:Chinese
-
Abstract:
The threat of antimicrobial resistance is escalating, and traditional antimicrobial susceptibility testing methods have long turnaround times, which are inadequate for rapid clinical decision-making. Consequently, the development of rapid antimicrobial susceptibility testing (RAST) methods that are fast, efficient, and cost-effective is of great significance. This review discusses the principles, characteristics, and application potentials of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry RAST, European Committee on Antimicrobial Susceptibility Testing RAST, Microfluidic RAST, Flow Cytometry RAST, Raman Spectroscopy RAST, and ultra-rapid antimicrobial susceptibility testing. These technologies exhibit significant advantages in reducing detection time and improving detection accuracy, but also face challenges such as high technical complexity, high costs, and limited applicability. It is expected that an ideal RAST will be realized in the future to better respond to the challenges of global antimicrobial resistance.
