Research progress on the impact and potential mechanisms of Helicobacter Pylori infection on immunotherapy for gastric cancer
10.12354/j.issn.1000-8179.2025.20250985
- VernacularTitle:幽门螺杆菌感染对胃癌免疫治疗影响及其潜在机制的研究进展
- Author:
Kang BO
1
;
Xu JINBIAO
;
Gu WEIGUO
;
Qiu FENG
Author Information
1. 南昌大学第一附属医院肿瘤科(南昌市 330006);南昌大学第一附属医院高新医院肿瘤科;南昌大学第一附属医院高新医院中心实验室
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori(Hp);
gastric cancer;
immunotherapy;
mechanism
- From:
Chinese Journal of Clinical Oncology
2025;52(17):903-909
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori(Hp)is a common pathogenic bacterium in the human digestive system.It has been classified as a group I car-cinogen by the International Agency for Research on Cancer under the World Health Organization in its published list of carcinogens.Im-munotherapy has brought new hope to patients with gastric cancer;however,in clinical practice,there are substantial individual differences in the response,and the poor therapeutic effect in some patients remains a bottleneck that urgently needs to be addressed.In recent years,a growing number of studies have shown that HP infection may be deeply involved in regulating the efficacy of gastric cancer immunother-apy through unique pathways,such as reshaping the tumor microenvironment and regulating immune checkpoint molecules expression.Re-search in this interdisciplinary field offers a new perspective on analyzing the mechanisms of immunotherapy resistance and holds import-ant exploratory value.This article systematically reviews the research progress on the impact of Hp on gastric cancer immunotherapy and its potential mechanisms,aiming to provide a theoretical basis and research directions to overcome therapeutic limitations and optimize indi-vidualized treatment strategies.
