New progress in laboratory testing of heparin-induced thrombocytopenia
10.3760/cma.j.cn114452-20250225-00106
- VernacularTitle:肝素诱导的血小板减少症实验室检测新进展
- Author:
Zixin CHEN
1
;
Zhou ZHOU
1
;
Yang ZHANG
1
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 实验诊断中心，北京 100037
- Publication Type:Journal Article
- Keywords:
Thrombocytopenia;
Heparin-induced thrombocytopenia;
Diagnosis;
Immunoassay;
Functional assay
- From:
Chinese Journal of Laboratory Medicine
2025;48(8):1095-1100
- CountryChina
- Language:Chinese
-
Abstract:
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder mediated by anti-PF4-heparin complex antibodies, leading to life-threatening thrombosis in severe cases. Currently, HIT diagnosis primarily relies on clinical presentation and laboratory testing, and the latter plays a crucial role. However, in China, HIT related lab tests mainly involve immunological screening, yet IgG-specific kits are lacking. Functional assays are difficult to implement in most clinical laboratories due to high technical and equipment requirements, as well as the radioactivity in some methods. In recent years, with the advancement of new technologies, methods such as flow cytometry and liquid chromatography-mass spectrometry have been increasingly applied in HIT diagnosis, showing potentials for improving diagnostic specificity and clinical feasibility.
