Laboratory diagnosis of congenital coagulation factor Ⅶ deficiency combined with antiphospholipid syndrome and literature review
10.3760/cma.j.cn114452-20250408-00223
- VernacularTitle:先天性凝血因子Ⅶ缺乏合并抗磷脂综合征患者1例
- Author:
Zhijun MENG
1
;
Guanqun XU
;
Yu LIU
;
Chi MA
;
Qiulan DING
;
Jing DAI
;
Wenman WU
;
Xuefeng WANG
Author Information
1. 山西省人民医院检验科，太原030012
- Publication Type:Journal Article
- Keywords:
Coagulation factor Ⅶ;
Gene deficiency;
Antiphospholipid syndrome;
Thrombosis
- From:
Chinese Journal of Laboratory Medicine
2025;48(8):1091-1094
- CountryChina
- Language:Chinese
-
Abstract:
Congenital coagulation factor Ⅶ deficiency is a rare autosomal incomplete recessive disorder caused by a defect in the coagulation factor Ⅶ (FⅦ) gene, with an incidence of approximately 1 in 500 000. Antiphospholipid antibody syndrome is relatively common and is a common cause of acquired thrombosis. However, the combination of the latter and the former is extremely rare in clinical practice, which brings difficulties to diagnosis and treatment. This article reported the laboratory examination, diagnosis and treatment of a patient with congenital coagulation factor Ⅶ deficiency and antiphospholipid syndrome after portal vein thrombosis, and reviewed the relevant literature.
