Research progress on the plasticity of tumor-associated macrophages and related treatment methods
10.12354/j.issn.1000-8179.2025.20250929
- VernacularTitle:肿瘤相关巨噬细胞的可塑性及相关治疗方法的研究进展
- Author:
Cheng ZERUN
1
;
Zhou TIAN
Author Information
1. 北京中医药大学岐黄学院(北京市 100029)
- Publication Type:Journal Article
- Keywords:
tumor-associated macrophages(TAM);
plasticity of TAM;
tumor immunotherapy;
tumor microenvironment(TME)
- From:
Chinese Journal of Clinical Oncology
2025;52(17):897-902
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated macrophages(TAMs)are critical components of the tumor microenvironment(TME)and represent an import-ant class of immune cells.Under the influence of various signaling factors,TAMs can be polarized into two major phenotypes:classic activa-tion of macrophage(M1)and alternative activation of macrophage(M2).M1-polarized TAMs predominantly exert pro-inflammatory and an-titumor effects,whereas M2-polarized TAMs are primarily associated with anti-inflammatory and tumor-promoting activities.Owing of their phenotypic plasticity,strategies aimed at reprogramming M2-type TAMs to adopt the M1 phenotype have emerged as promising and novel approaches in cancer therapy.Significant progress has been made through multifaceted investigations that include in vitro studies,use of an-imal models,and clinical research.This review summarizes the plasticity of TAMs,their functional roles in different types of cancers,and re-cently reported therapeutic strategies targeting TAM polarization.
