Correlation between preoperative serum CA19-9 and pathological characteristics of pseudomyxoma peritonei
10.12354/j.issn.1000-8179.2025.20250837
- VernacularTitle:术前血清CA19-9与腹膜假黏液瘤病理特征的相关性研究
- Author:
Wei TIAN
1
;
Wang SHULI
1
;
Li YAN
1
Author Information
1. 清华大学北京清华长庚医院腹膜肿瘤科(北京市 102218)
- Publication Type:Journal Article
- Keywords:
pseudomyxoma peritonei(PMP);
CA19-9;
pathological grade;
overall survival
- From:
Chinese Journal of Clinical Oncology
2025;52(17):865-869
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between preoperative serum CA19-9 levels and pathological grades in pseudomyxoma peritonei(PMP)and evaluate its impact on overall survival.Methods:A retrospective analysis was conducted on clinical data from 321 pa-tients with PMP who underwent initial cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy(CRS+HIPEC)by our team between October 2004 and October 2024.Receiver operating characteristic curve analysis was used to assess the discriminative value of CA19-9 for the pathological grade.Kaplan-Meier analysis was conducted to evaluate the impact of preoperative CA19-9 on overall survival.Results:Among the 321 patients included in this study,148(46.1%)had increased preoperative CA19-9 levels,which were associated with pathological grades.When preoperative CA19-9>693.3 U/mL,the pathological grade was more likely to be high-grade peritoneal mucinous carcinoma with signet ring cells(area under the curve:0.67,95%confidence interval:0.54-0.80,P=0.021).Elevated preoperative CA19-9 was an independent risk factor for overall survival in patients with PMP(mOS was 53.62 m vs.not reached in the elevated group vs.normal group,respectively,P<0.001).Conclusions:Preoperative serum CA19-9 levels were associated with pathological grades in patients with PMP undergoing initial CRS+HIPEC,with an independent negative impact on overall survival.
