Analysis on the Current Status of Clinical Trial Registries of TCM in Prevention and Treatment of Osteoporosis
10.19879/j.cnki.1005-5304.202412578
- VernacularTitle:中医药防治骨质疏松症临床试验注册现状分析
- Author:
Chongyang ZHANG
1
;
Bo LIU
;
Jian HUANG
;
Wenping LIN
Author Information
1. 广州中医药大学,广东 广州 510405;广州中医药大学附属深圳平乐骨伤科医院,广东 深圳 518010
- Publication Type:Journal Article
- Keywords:
osteoporosis;
traditional Chinese medicine;
ChiCTR;
ClinicalTrials.gov;
clinical trial
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(11):56-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the research status and development direction by analyzing the registered clinical trials of TCM prevention and treatment of osteoporosis.Methods The clinical trials of TCM in the prevention and treatment of osteoporosis were retrieved from Chinese Clinical Trial Registry(ChiCTR)and the ClinicalTrials.gov from the establishment of databases to September 2024.Excel 2024 was used to input the screening data,and the registration number,research topic,registration time,region,institution,funding source,research disease,research type,stage and design scheme,randomized method and blind method,intervention measures,participation center,sample size and outcome index of the included trials were analyzed.Results A total of 101 clinical trials of TCM in the prevention and treatment of osteoporosis were included in the study,involving 4 countries.China's registered projects involved 58 research institutions in 21 provincial administrative regions,of which Beijing,Shanghai and Guangzhou had a large number of registered projects;the studies were dominated by single-center,interventional,and randomized controlled trials,with the most application of simple randomization methods;blinding was applied to 20 trials;postmenopausal osteoporosis was the dominant disease under study,and Chinese patent medicines were the main interventions;the main outcome indicators were bone mineral density,biochemical indicators of bone metabolism and visual analog score.Conclusion The number of clinical trials of TCM in the prevention and treatment of osteoporosis has been increasing rapidly,and researchers have been paying more attention to the studies.However,there are some problems,such as unbalanced research area,less preventive and observational research,insufficient use of blind method,unclear outcome indicators,and low attention paid to some treatment methods.
