Research update on the pathogenic mechanisms of dysregulated lipid metabolism induced blindness and clinical value of lipid metabolism modulation
10.3760/cma.j.cn114452-20250328-00199
- VernacularTitle:脂代谢异常致盲机制及临床应用
- Author:
Shengliu PAN
1
;
Jialiang YANG
;
Xingwei WU
;
Zhenglin YANG
Author Information
1. 中国科学院大学 中国科学院成都生物研究所天然产物中心 电子科技大学附属医院·四川省人民医院人类疾病基因研究重点实验室，成都 610072
- Publication Type:Journal Article
- Keywords:
Lipid metabolism;
Glaucoma;
Degeneration of macula;
Diabetic retinopathy;
Optic atrophy;
Pathogenic mechanisms
- From:
Chinese Journal of Laboratory Medicine
2025;48(7):795-801
- CountryChina
- Language:Chinese
-
Abstract:
Dysregulated lipid metabolism can lead to multi-organ dysfunction, particularly the cardiovascular diseases. Increasing evidence indicates that lipid metabolism abnormalities also play a significant role in various ocular diseases, especially in blinding diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy, and optic atrophy. Lipid dysregulation not only directly affects the structure and function of ocular tissues but also exacerbates optic nerve damage and retinal degeneration by modulating inflammation, apoptosis, and oxidative stress. This review summarizes the relationship between lipid metabolism disorders and ocular diseases, explores the pathogenic mechanisms involved in vision loss, and discusses the potential clinical applications of lipid metabolism modulation, particularly in early diagnosis, therapeutic strategies, and preventive interventions.
