Key technical issues on the precision dosing of antimicrobial agents
10.3760/cma.j.cn114452-20250529-00314
- VernacularTitle:抗菌药物精准用药的关键技术问题
- Author:
Wenqi QIAN
1
;
Yaxin FAN
1
;
Lin XI
1
;
Jing ZHANG
1
Author Information
1. 复旦大学附属华山医院抗生素研究所，国家卫生健康委员会抗生素临床药理重点实验室，复旦大学附属华山医院临床药理研究中心，复旦大学附属华山医院国家老年疾病临床医学研究中心，上海200040
- Publication Type:Journal Article
- Keywords:
Artificial intelligence;
Anti-bacterial agents;
Individualized therapy;
Therapeutic drug monitoring
- From:
Chinese Journal of Laboratory Medicine
2025;48(9):1110-1116
- CountryChina
- Language:Chinese
-
Abstract:
The precision dosing of antimicrobial agents serves as a key strategy to improve effectiveness while minimizing adverse drug effects, thereby enhancing therapeutic outcomes. It also aims to reduce the risk of antimicrobial resistance and optimize the utilization of healthcare resource. This article reviews the key technical elements of antimicrobial precision dosing, including novel therapeutic drug monitoring (TDM) methods, the concepts, modelling and stimulation approaches, and model evaluation of model-informed precision dosing (MIPD), and the implementation of MIPD with clinical decision support system (CDSS). Meanwhile, applications on how artificial intelligence (AI) techniques facilitate MIPD are discussed. We hope that the advances discussed and perspectives presented in this article will provide insights into the precision dosing and individualized therapy of antimicrobials in clinical practice.
