The impact of immunotherapy on pulmonary function and its prognostic significance in patients with non-small cell lung cancer
10.12354/j.issn.1000-8179.2025.20251032
- VernacularTitle:免疫治疗对非小细胞肺癌患者肺功能的影响及其预后意义
- Author:
Zhao HUIRU
1
;
Jia JUNMEI
Author Information
1. 山西医科大学第一临床医学院(太原市 030001);山西医科大学第一医院肿瘤呼吸科
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer(NSCLC);
immunotherapy;
immune checkpoint inhibitors(ICIs);
pulmonary function;
prognosis
- From:
Chinese Journal of Clinical Oncology
2025;52(16):860-864
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer(NSCLC)is the most common form of lung cancer,and patients with advanced disease generally have a poor prognosis.In recent years,immune checkpoint inhibitors(ICIs)have been approved as first-line therapy for patients with NSCLC lacking actionable driver mutations.Emerging evidence indicates that ICIs reduce tumor burden in some patients and may affect pulmonary ventila-tion and diffusion capacity,which are associated with clinical outcomes.This review summarizes baseline pulmonary function characteristics in advanced NSCLC,outlines in the impact of ICI therapy on lung function,and discusses potential mechanisms through which immunother-apy can influence pulmonary function,with the aim of guiding lung function monitoring and individualized management during ICI treat-ment.
