Analysis of patch test in 186 patients with rosacea
10.3760/cma.j.cn114452-20250121-00037
- VernacularTitle:玫瑰痤疮患者186例斑贴试验结果分析
- Author:
Shuanglu LIAO
1
;
Jing PAN
;
Yaqi ZHENG
;
Yan WU
;
Haixia LI
;
Shaomin ZHONG
Author Information
1. 北京大学第一医院皮肤性病科，国家皮肤与免疫疾病临床医学研究中心，北京市皮肤病分子诊断重点实验室，国家药品监督管理局化妆品质量控制与评价重点实验室，北京100034
- Publication Type:Journal Article
- Keywords:
Acne rosacea;
Allergens;
Patch tests;
Skin contact allergy
- From:
Chinese Journal of Laboratory Medicine
2025;48(6):701-706
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze patch test results in patients with rosacea, investigate the prevalence of contact sensitization, and identify common allergens, to provide relevant evidence for the diagnosis, treatment, and preventive interventions for rosacea.Methods:A cross-sectional retrospective survey was conducted to analyze the positive contact allergy rate and allergen distribution in 186 rosacea patients who underwent the 60-item China Standard Series Patch Test (CB-1000) at the Department of Dermatology, Peking University First Hospital, from January 2023 to September 2024.Results:Among the 186 patients, 159(85.5%) showed positive reactions in patch tests. The top three allergens with the highest positivity rates were: metal salts, preservatives and fragrances. The top 10 individual allergens with the highest positivity rates were: nickelsulfate hexahydrate 46.8%(87/186), cobaltchloride hexahydrate 29.0%(54/186), hydroperoxides of linalool 15.1%(28/186), carba mix 14.0%(26/186), propolis 9.7%(18/186), fragrance mix Ⅰ 8.6%(16/186), methyl dibromo glutaronitrile 8.1%(15/186), Peru balsam 7.5%(14/186), gold sodium thiosulfate dihydrate 7.5%(14/186), and hydroperoxides of limonene 7.5%(14/186). The overall positivity rate for cosmetics-related allergens was 56.5% (105/186), with the top five allergens being: hydroperoxide of linalool 15.1%(28/186), propolis 9.7%(18/186), fragrance mix Ⅰ 8.6%(16/186), methyl dibromo glutaronitrile 8.1%(15/186), and Peru balsam 7.5%(14/186).Conclusion:The overall positivity rate for patch test allergens in rosacea patients is high. The most common allergen types are metal salts, preservatives, and fragrance agents. Cosmetics-related allergens also show a high positivity rate. Rosacea patients should avoid exposure to these allergens.
