Establishment of quantitative models for effective components in Yishen Xiezhuo Mixture
10.3969/j.issn.1001-1528.2025.10.001
- VernacularTitle:益肾泄浊合剂中有效成分定量模型建立
- Author:
Zi-fang FENG
1
;
Min-min HU
;
Xiao-wei CHEN
;
Wen-ming ZHANG
;
Li-hong GU
;
Ping QIN
;
Yi PENG
;
Zhen-hua BIAN
;
Qing-you YANG
;
Tu-lin LU
Author Information
1. 南京中医药大学附属无锡医院,江苏无锡 214074
- Publication Type:Journal Article
- Keywords:
Yishen Xiezhuo Mixture;
effective components;
quantitative models;
near-infrared spectroscopy(NIRS);
partial least square method(PLS)regression analysis;
competitive adaptive reweighting sampling(CARS)algorithm
- From:
Chinese Traditional Patent Medicine
2025;47(10):3177-3184
- CountryChina
- Language:Chinese
-
Abstract:
AIM To establish the quantitative models for gallic acid,mononucleoside,loganin,resveratrol,and rhein in Yishen Xiezhuo Mixture.METHODS HPLC was adopted in the content determination of various effective components,after which the near-infrared spectroscopy(NIRS)data were collected in 128 batches of samples and pretreatment was conducted,competitive adaptive reweighting sampling(CARS)algorithm was used for screening wavelength,partial least square method(PLS)regression analysis was performed.RESULTS There were no significant differences between the predicted values obtained by PLS models and measured values obtained by HPLC for various effective components(P＞0.05).CONCLUSION The quantitative models established by NIRS combined with chemometrics display good predictive performance,which can be used for the rapid determination of effective components in Yishen Xiezhuo Mixture,and provide a reference for the rapid monitoring of other traditional Chinese medicine preparations in production processes.
